Bringing Kierkegaard into anthropology: Repetition, absurdity, and curses in Fiji

The Danish philosopher Søren Kierkegaard offers two concepts that can strengthen anthropological analyses of Christianity. The first is "repetition," or the act of "recollecting forward," which provides a model of transformation that depends neither on

Rebuilding Albert : reconstruction and remembrance on the Western Front, 1914-1932

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Office-Based Deep Sedation for Pediatric Ophthalmologic Procedures Using a Sedation Service Model

Aims. (1) To assess the efficacy and safety of pediatric office-based sedation for ophthalmologic procedures using a pediatric sedation service model. (2) To assess the reduction in hospital charges of this model of care delivery compared to the operating room (OR) setting for similar procedures. Background. Sedation is used to facilitate pediatric procedures and to immobilize patients for imaging and examination. We believe that the pediatric sedation service model can be used to facilitate office-based deep sedation for brief ophthalmologic procedures and examinations. Methods. After IRB approval, all children who underwent office-based ophthalmologic procedures at our institution between January 1, 2000 and July 31, 2008 were identified using the sedation service database and the electronic health record. A comparison of hospital charges between similar procedures in the operating room was performed. Results. A total of 855 procedures were reviewed. Procedure completion rate was 100% (C.I. 99.62–100). There were no serious complications or unanticipated admissions. Our analysis showed a significant reduction in hospital charges (average of $1287 per patient) as a result of absent OR and recovery unit charges. Conclusions. Pediatric ophthalmologic minor procedures can be performed using a sedation service model with significant reductions in hospital charges

2T-POT Hawkes model for left- and right-tail conditional quantile forecasts of financial log-returns: out-of-sample comparison of conditional EVT models

Conditional extreme value theory (EVT) methods promise enhanced forecasting of the extreme tail events that often dominate systemic risk. We present an improved two-tailed peaks-over-threshold (2T-POT) Hawkes model that is adapted for conditional quantile forecasting in both the left and right tails of a univariate time series. This is applied to the daily log-returns of six large cap indices. We also take the unique step of fitting the model at multiple exceedance thresholds (from the 1.25% to 25.00% mirrored quantiles). Quantitatively similar asymmetries in Hawkes parameters are found across all six indices, adding further empirical support to a temporal leverage effect in financial price time series in which the impact of losses is not only larger but also more immediate. Out-of-sample backtests find that our 2T-POT Hawkes model is more reliably accurate than the GARCH-EVT model when forecasting (mirrored) value-at-risk and expected shortfall at the 5% coverage level and below. This suggests that asymmetric Hawkes-type arrival dynamics are a better approximation of the true data generating process for extreme daily log-returns than GARCH-type conditional volatility; our 2T-POT Hawkes model therefore presents a better performing alternative for financial risk modelling.Comment: Main paper: 25 pages, 7 figures, 6 tables. Supplementary material: 12 pages, 14 figure

Asymmetric excitation of left- and right-tail extreme events probed using a Hawkes model: Application to financial returns

We construct a two-tailed peak-over-threshold Hawkes model that captures asymmetric self- and cross-excitation in and between left- and right-tail extreme values within a time series. We demonstrate its applicability by investigating extreme gains and losses within the daily log-returns of the S&P 500 equity index. We find that the arrivals of extreme losses and gains are described by a common conditional intensity to which losses contribute twice as much as gains. However, the contribution of the former decays almost five times more quickly than that of the latter. We attribute these asymmetries to the different reactions of market traders to extreme upward and downward movements of asset prices: an example of negativity bias, wherein trauma is more salient than euphoria.Comment: 11 pages. 7 figures and 5 table

Flavonoids from engineered tomatoes inhibit gut barrier pro-inflammatory cytokines and chemokines, via SAPK/JNK and p38 MAPK pathways

Flavonoids are a diverse group of plant secondary metabolites, known to reduce inflammatory bowel disease symptoms. How they achieve this is largely unknown. Our study focuses on the gut epithelium as it receives high topological doses of dietary constituents, maintains gut homeostasis, and orchestrates gut immunity. Dysregulation leads to chronic gut inflammation, via dendritic cell (DC)-driven immune responses. Tomatoes engineered for enriched sets of flavonoids (anthocyanins or flavonols) provided a unique and complex naturally consumed food matrix to study the effect of diet on chronic inflammation. Primary murine colonic epithelial cell-based inflammation assays consist of chemokine induction, apoptosis and proliferation, and effects on kinase pathways. Primary murine leukocytes and DCs were used to assay effects on transmigration. A murine intestinal cell line was used to assay wound healing. Engineered tomato extracts (enriched in anthocyanins or flavonols) showed strong and specific inhibitory effects on a set of key epithelial pro-inflammatory cytokines and chemokines. Chemotaxis assays showed a resulting reduction in the migration of primary leukocytes and DCs. Activation of epithelial cell SAPK/JNK and p38 MAPK signaling pathways were specifically inhibited. The epithelial wound healing-associated STAT3 pathway was unaffected. Cellular migration, proliferation, and apoptosis assays confirmed that wound healing processes were not affected by flavonoids. We show flavonoids target epithelial pro-inflammatory kinase pathways, inhibiting chemotactic signals resulting in reduced leukocyte and DC chemotaxis. Thus, both anthocyanins and flavonols modulate epithelial cells to become hyporesponsive to bacterial stimulation. Our results identify a viable mechanism to explain the in vivo anti-inflammatory effects of flavonoids

Mathematical modelling of tissue-engineering angiogenesis

We present a mathematical model for the vascularisation of a porous scaffold following implantation in vivo. The model is given as a set of coupled non-linear ordinary differential equations (ODEs) which describe the evolution in time of the amounts of the different tissue constituents inside the scaffold. Bifurcation analyses reveal how the extent of scaffold vascularisation changes as a function of the parameter values. For example, it is shown how the loss of seeded cells arising from slow infiltration of vascular tissue can be overcome using a prevascularisation strategy consisting of seeding the scaffold with vascular cells. Using certain assumptions it is shown how the system can be simplified to one which is partially tractable and for which some analysis is given. Limited comparison is also given of the model solutions with experimental data from the chick chorioallantoic membrane (CAM) assay

Independent and combined effects of diethylhexyl phthalate and polychlorinated biphenyl 153 on sperm quality in the human and dog

A temporal decline in human and dog sperm quality is thought to reflect a common environmental aetiology. This may reflect direct effects of seminal chemicals on sperm function and quality. Here we report the effects of diethylhexyl phthalate (DEHP) and polychlorinated biphenyl 153 (PCB153) on DNA fragmentation and motility in human and dog sperm. Human and dog semen was collected from registered donors (n = 9) and from stud dogs (n = 11) and incubated with PCB153 and DEHP, independently and combined, at 0x, 2x, 10x and 100x dog testis concentrations. A total of 16 treatments reflected a 4 × 4 factorial experimental design. Although exposure to DEHP and/or PCB153 alone increased DNA fragmentation and decreased motility, the scale of dose-related effects varied with the presence and relative concentrations of each chemical (DEHP.PCB interaction for: DNA fragmentation; human p < 0.001, dog p < 0.001; Motility; human p < 0.001, dog p < 0.05). In both human and dog sperm, progressive motility negatively correlated with DNA fragmentation regardless of chemical presence (Human: P < 0.0001, r = −0.36; dog P < 0.0001, r = −0.29). We conclude that DEHP and PCB153, at known tissue concentrations, induce similar effects on human and dog sperm supporting the contention of the dog as a sentinel species for human exposure

Measurement Properties of the Motivation for Youth Treatment Scale with a Residential Group Home Population

A client’s motivation to receive services has long been identified as a highly relevant component of mental health treatment. In fact, ample evidence demonstrates that client motivation is significantly related to seeking services, remaining in services, and improved client outcomes (e.g., Broome, Joe, & Simpson, 2001; Ryan, Plant, & O’Malley, 1995; Schroder, Sellman, Frampton, & Deering, 2009). Additionally, it has been recognized that motivation is a “dynamic” characteristic that changes throughout treatment (Melnick, De Leon, Hawke, Jainchill, & Kressel, 1997; Schroder et al., 2009). In this way, motivation is an important client factor to assess and monitor throughout the treatment process. The broad construct of motivation is comprised of two separate, but related components conceptualized as motivation to change and motivation for treatment. As defined by DiClamente, Schlundt, and Gemmell (2004), motivation to change refers to a willingness to recognize problematic behavior and take steps toward change, whereas motivation for treatment refers to a willingness to seek help and remain compliant with an intervention program. In other words, a motivated person not only perceives the importance of changing, but also has confidence that they are able to be successful at making the change (Burke, Arkowitz, & Menchola, 2003)

Gene Expression and Discovery During Lens Regeneration in Mouse: Regulation of Epithelial to Mesenchymal Transition and Lens Differentiation

Purpose: It has been shown that after extracapsular lens removal by anterior capsulotomy in the mouse, the lens can be regenerated. However, as the capsular bag is filled with fibers, epithelial to mesenchymal transition (EMT), an event which is common after cataract surgery as well, takes place during early stages. This study, using a unique mouse model, was undertaken to identify novel regulators and networks in order to more clearly understand secondary cataracts at the molecular level